With the rapid development of software techniques, domain-driven software raises new challenges in software security and robustness. Symbolic execution and fuzzing have been rapidly developed in recent decades, demonstrating their ability in detecting software bugs. Enormous detected and fixed bugs demonstrate their feasibility. However, it is still a challenging task to combine the two methods due to their corresponding weakness. State-of-the-art techniques focus on incorporating the two methods such as using symbolic execution to solve paths when fuzzing gets stuck in complex paths. Unfortunately, such methods are inefficient because they have to switch to fuzzing (resp. symbolic execution) when conducting symbolic execution (resp. fuzzing). This paper presents a new deep learning-based hybrid testing method using symbolic execution and fuzzing. This method tries to predict paths that are suitable for fuzzing (resp. symbolic execution) and guide the fuzzing (resp. symbolic execution) to reach the paths. To further enhance the effectiveness, a hybrid mechanism is proposed to make them interact with each other. The proposed approach is evaluated on the programs in LAVA-M, and the results are compared with that using symbolic execution or fuzzing independently. The proposed method achieves more than 20% increase of branch coverage, 1 to 13 times increase of the path number, and uncover 929 more bugs.