Control flow is an abstract expression of the program process, and it is of critical significance to obfuscate the control flow to effectively reinforce the code’s ability to resist reverse manners. This study proposes the idea of deep control flow: as for the loop structure, the callback function is utilized to construct an equivalent loop model, and the basic block in the program process is converted into inter-process function calling to counter reverse technology. This study comprehensively applies control flow analysis and data flow dependency analysis to establish a deep control flow obfuscation model based on callback function and gives proof of functional consistency. To further enhance obfuscation, the function calling fusion algorithm is designed and implemented pertinently to construct a more sophisticated function calling process. Finally, OpenSSL and SPECint-2000 benchmark suite is used as the test set to verify the feasibility and effectiveness of the proposed model.