Computer aided detection/diagnosis (CAD) can improve the accuracy of diagnosis,reduce false positive,and provide decision supports for doctors.The main purpose of this paper is to analyze the latest development of computer aided diagnosis tools.Focusing on the top four fatal cancer's incidence positions,major recent publications on CAD applications in different medical imaging areas are reviewed in this survey according to different imaging techniques and diseases.Further more,multidimentional analysis is made on the researches from image data sets,algorithms and evaluation methods.Finally,existing problems,research trend and development direction in the field of medical image CAD system are discussed.