As a high energy consumption component of embedded devices, the power consumption of AMOLED displays is determined by the pixel value of all pixels of the displayed content. And human visual system gives priority to the important regions of the display content, while pays less attention to the unimportant region. Based on the above features, a power optimization method is proposed for AMOLED display based on multi-region visual saliency. The core of the method is to extract the important region of the display content by the multi-region visual saliency algorithm, and then the display content is divided into multiple regions according to saliency map of important region of the image. At last, the dynamic pixel adjustment is carried out based on the visual attention level, which minimizes the display power without reducing the overall visual effect of the display content. Finally, through a number of image testing, the results show that the power consumption of image can be reduced while maintaining a good visual effect.