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首页 > 过刊浏览>2019年第30卷第4期 >1094-1105. DOI:10.13328/j.cnki.jos.005367
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SNP连锁不平衡下的基因隐私保护模型
作者:
作者简介:

刘海(1989-),男,贵州遵义人,博士生,主要研究领域为生物医学大数据隐私保护;彭长根(1963-),男,博士,教授,博士生导师,CCF专业会员,主要研究领域为密码学,信息安全,大数据隐私保护;吴振强(1968-),男,博士,教授,博士生导师,CCF高级会员,主要研究领域为网络与信息安全,分布式计算,数据隐私保护;雷秀娟(1975-),女,博士,教授,博士生导师,CCF高级会员,主要研究领域为生物信息计算,智能计算.

通讯作者:

吴振强,E-mail:zqiangwu@snnu.edu.cn

基金项目:

国家自然科学基金（61173190，61602290，61672334，61662009）；中央高校基本科研业务费专项资金（2016CBY004，GK201704016，GK201501008）；陕西省重点科技创新团队（2014KTC-18）


Genomic Privacy Preserving Framework for SNP Linkage Disequilibrium
Author:
Fund Project:

National Natural Science Foundation of China (61173190, 61602290, 61672334, 61662009); Fundamental Research Funds for the Central Universities (2016CBY004, GK201704016, GK201501008); Key Science and Technology Innovation Team in Shaanxi Province (2014KTC-18)

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    摘要:

    人类基因测序技术的快速发展，测序成本大幅降低，使基因数据得到广泛的应用，在全基因组的单核苷酸多态性与疾病关联研究中，单核苷酸多态性与患者的身份、表型和血缘关系等敏感信息相关联，单核苷酸多态性连锁不平衡容易导致患者的隐私信息泄露.为此，基于单核苷酸多态性连锁不平衡相关系数，提出矩阵差分隐私保护模型以实现基因数据和单核苷酸多态性连锁不平衡的隐私保护，同时确保基因数据具有一定的效用.该模型可以实现单核苷酸多态性连锁不平衡下全基因组关联研究中基因数据隐私与效用的权衡，并对单核苷酸多态性连锁不平衡下的基因隐私保护具有促进作用.

    Abstract:

    The cost of sequencing is substantially decreasing with the rapid development of human genome sequencing technologies. The generated genome data are supporting various applications. The genome-wide associated analysis study between the single nucleotide polymorphisms and diseases may lead to more privacy breaches for considering single nucleotide polymorphisms linkage disequilibrium, because of sensitive information related to single nucleotide polymorphisms including individual identity, phenotype, and kinship. To this end, the matrix differential privacy preserving framework is proposed based on the correlated coefficient of single nucleotide polymorphisms linkage disequilibrium. Therefore, this framework can preserve privacy of genome data and single nucleotide polymorphisms linkage disequilibrium, while ensures a certain genome data utility. And it achieves the trade-off between genome data privacy and utility for single nucleotide polymorphisms linkage disequilibrium in genome-wide association studies. Furthermore, the proposed framework plays an important role for promoting genomic privacy preserving under single nucleotide polymorphisms linkage disequilibrium.

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刘海,吴振强,彭长根,雷秀娟. SNP连锁不平衡下的基因隐私保护模型.软件学报,2019,30(4):1094-1105

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  • 收稿日期:2017-06-01
  • 最后修改日期:2017-07-13
  • 在线发布日期: 2019-04-01
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