MIMO (multi-input multi-output), a promising technology that hopes to improve reliability and bandwidth of wireless networks, has been widely deployed. However there has been little literature that describes how to provide high-quality video service for multi-user over MIMO multi-hop wireless networks. The co-channel interference among multiple wireless links is one of the critical issues. This paper proposes a scheme for multi-user video transmission over multi-hop wireless networks and combats with interference by employing link selection, spatial multiplexing and spatial diversity gain of MIMO. Furthermore, the study formulates this scheme as an optimization problem, which is a NP-hard problem. To make it suitable for practical implementation, the study employs a modified genetic algorithm to solve the link selection problem. Moreover, according to the characteristics of scalable video and MIMO, the antenna grouping problem is transformed into one 0/1 knapsack problem. The depth first search and branch bound techniques are used to further reduce the searching range. The study demonstrate the effectiveness of the proposed scheme by extensive experiments.