In spatial information processing, spatial information is usually combined with various spatial relationships, which are often dynamic. To represent and reason with these complex spatial relationships effectively, a novel model topology-direction-size calculus (TDSC) is proposed, which is integrated with multi-aspects qualitative spatial relations. Then, a framework for dealing with dynamic qualitative spatial relations is proposed. First, a base relation set which integrated with multi-aspects is constructed. Next, the algorithm of constructing composition table is proposed for reasoning, which allows the reasoning result of original model to still be used in new model. To handle the dynamic spatial relations, the neighborhood partition graph (NPG) is proposed, and an algorithm is give to generate the GNP. Using this algorithm, one can get the new model’s GNP easily. Finally, the framework for handing dynamic spatial relations is proposed, which is based on the new model TDSC and its GNP. An example is used to show the framework is correct and effective.