针刺效应的神经影像学研究
作者:
基金项目:

Supported by the National Natural Science Foundation of China under Grant Nos.30873462, 90209008, 30672690, 30870685, 30600151, 60532050, 60621001 (国家自然科学基金); the National Basic Research Program of China under Grant No.2006CB705700 (国家重点基础研究发展计划(973)); the National High-Tech Research and Development Plan of China under Grant No.2008AA01Z411 (国家高技术研究发展计划(863)); the Program for Cheung Kong Scholars and Innovative Research Team in University of China under Grant No.IRT0645 (长江学者和创新团队发展计划); the Program for Chair Professors of “Cheung Kong Scholars Program” of China (“长江学者奖励计划”特聘教授); the Joint Research Fund for Overseas Chinese Young Scholars under Grant No.30528027 (海外青年学者合作研究基金); the Beijing Municipal Natural Science Foundation of China under Grant No.4071003 (北京市自然科学基金)

  • 摘要
  • | |
  • 访问统计
  • |
  • 参考文献 [68]
  • |
  • 相似文献
  • |
  • 引证文献
  • | |
  • 文章评论
    摘要:

    介绍了研究针刺机理的神经影像技术方法:fMRI(functional magnetic resonance imaging),PET(positron emission tomography),EEG(electroencephalography)和MEG(magnetoencephalography).介绍了针刺研究中穴位点和对照方法的选取.分别从针刺对于大脑网络、边缘系统和自主神经系统的调节3个方面概述了针刺效应神经生理机制的研究成果.指出了目前的研究所存在的问题,并对未来的研究进行展望.总结和概述了目前针刺效应的神经影像学研究和进展,希望有助于加速针刺机理的研究和认识,早日揭示针刺机理,发扬祖国传统医学.

    Abstract:

    This paper introduces modern medical imaging technologies (fMRI (functional magnetic resonance imaging), PET(positron emission tomography), EEG(electroencephalography) and MEG(magnetoencephalography)) for deeper exploration in the field of acupuncture. Based on the experimental design and acupoint selection, acupuncture’s regulation of the brain functional network, paralimbic system, brain stem network and its control of the endogenous analgesic system as well as the autonomic nervous system are presented from three aspects. This paper summarizes the imaging technology-related academic reports used in the neural mechanisms of acupuncture. It simultaneously depicts the problems in current acupuncture studies and provides a better framework for future experimental work in hope of further understanding the neural mechanisms of acupuncture.

    参考文献
    [1] Lin ZG, Yan L. Acupuncuture Medical History. Beijing: China Press of Traditional Chinese Medicine, 1995 (in Chinese).
    [2] Ten Lectures on the Meridian Compose Group. Ten Lectures on the meridian. Shanghai: Shanghai People’s Publishing House, 1976 (in Chinese).
    [3] Wang QC, Gao JX. Meridian Research and Clinical Application. Beijing: Shanghai Guji Press, 1998 (in Chinese).
    [4] Zhu B. The Scientific Basis for Acupuncture. Qingdao: Qingdao Publishing House, 1998 (in Chinese).
    [5] NIH Consensus Conference. Acupuncture. Journal of the American Medical Association, 1998,280(17):1518?1524. http://www. ncbi.nlm.nih.gov/pubmed/9809733
    [6] Ellis A, Wiseman N, Boss K. Fundamentals of Chinese Acupuncture. Paradigm Publications, 2004.
    [7] Stux G, Hammerschlag R. Clinical Acupuncture: Scientific Basis. Seattle: Springer-Verlag, 2001.
    [8] Abel KM, Allin MPG, Kucharska-Pietura K, Andrew C, Williams S, David AS, Phillips ML. Ketamine and fMRI BOLD signal: Distinguishing between effects mediated by change in blood flow versus change in cognitive state. Human Brain Mapping, 2003,18(2):135?45.
    [9] Abel KM, Allin MPG, Kucharska-Pietura K, David A, Andrew C, Williams S, Brammer MJ, Phillips ML. Ketamine alters neural processing of facial emotion recognition in healthy men: An fMRI study. Neuroreport, 2003,14(3):387?91.
    [10] Anand A, Li Y, Wang Y, Wu JW, Gao SJ, Bukhari L, Mathews VP, Kalnin A, Lowe MJ. Activity and connectivity of brain mood regulating circuit in depression: A functional magnetic resonance study. Biological Psychiatry, 2005,57(10):1079?88.
    [11] Han J, Ma L. Functional magnetic resonance imaging study of the brain in patients with amyotrophic lateral sclerosis. Chinese Medical Sciences Journal, 2006,21(4):228?33.
    [12] Han JS, Terenius L. Neurochemical basis of acupuncture analgesia. Annual Review of Pharmacology and Toxicology, 1982,22(1): 193?220.
    [13] Han JS. Acupuncture: Neuropeptide release produced by electrical stimulation of different frequencies. Trends in Neurosciences, 2003, 26(1):17?22.
    [14] Moonen CTW, Bandettini PA. Functional MRI. Berlin: Springer-Verlag, 1999.
    [15] Toga AW, Mazziota JC. Brain Mapping: The Methods. 2nd ed., San Diego: Academic Press, Elsevier Science, 2002.
    [16] Kwong KK, Belliveau JW, Chesler DA, Goldberg IE, Weisskoff RM, Poncelet BP, Kennedy DN, Hoppel BE, Cohen MS, Turner R, Cheng HM, Brady TJ, Rosen BR. Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc. of the National Academy of Sciences of the United States of America, 1992,89(12):5675?5679.
    [17] Ogawa S, Tank DW, Menon R, Ellermann JM, Kim SG, Merkle H, Ugurbil K. Intrinsic signal changes accompanying sensory stimulation: Functional brain mapping with magnetic resonance imaging. Proc. of the National Academy of Sciences of the United States of America, 1992,89(13):5951?5955.
    [18] Wu MT, Hsieh JC, Xiong J, Yang CF, Pan HB, Chen YC, Tsai GC, Rosen BR, Kwong KK. Central nervous pathway for acupuncture stimulation: Localization of processing with functional MR imaging of the brain-preliminary experience. Radiology, 1999,212(1):133?141.
    [19] Hui KK, Liu J, Makris N, Gollub RL, Chen AJ, Moore CI, Kennedy DN, Rosen BR, Kwong KK. Acupuncture modulates the limbic system and subcortical gray structures of the human brain: Evidence from fMRI studies in normal subjects. Human Brain Mapping, 2000,9(1):13?25.
    [20] Dhond RP, Kettner N, Napadow V. Neuroimaging acupuncture effects in the human brain. The Journal of Alternative and Complement Medicine, 2007,13(6):603?616.
    [21] Rosen BR, Buckner RL, Dale AM. Event-Related functional MRI: Past, present, and future. Proc. of the National Academy of Sciences of the United States of America, 1998,95(3):773?780.
    [22] Shibasaki H. Human brain mapping: Hemodynamic response and electrophysiology. Clinical Neurophysiology, 2008,119(4): 731?743.
    [23] Alan G, Jian L, Paul B, Bryan R, John D. Seeing through the skull: Advanced EEGs use MRIs to accurately measure cortical activity from the scalp. Brain Topography, 1991,4(2):125?131.
    [24] Hamalainen M, Hari R. Magnetoencephalographic characterization of dynamic brain activation: Basic principles and methods of data collection and source analysis. In: Toga AW, Mazziotta JC, eds. Brain Mapping: The Methods. 2nd ed., San Diego: Academic Press, 2002.
    [25] Niedermeyer E, Lopes da Silva F. Electroencephalography: Basic Principles, Clinical Applications and Related Fields. 4th ed., Lippincott: Williams & Wilkins, 2004.
    [26] Portin K, Salenius S, Salmelin R, Hari R. Activation of the human occipital and parietal cortex by pattern and luminance stimuli:
    [27] Gray CM, Konig P, Engel AK, Singer W. Oscillatory responses in cat visual cortex exhibit inter-columnar synchronization which reflects global stimulus properties. Nature, 1989,338(6213):334?337.
    [28] Hari R, Salmelin R. Human cortical oscillations: A neuromagnetic view through the skull. Human Cortical Rhythms, 1997,20(1): 44?49.
    [29] Nakagoshi A, Fukunaga M, Umeda M, Mori Y, Higuchi T, Tanaka C. Somatotopic representation of acupoints in human primary somatosensory cortex: Magnetic Resonance in Medical Science, 2005,4(4):187?189.
    [30] Cho ZH, Chung SC, Jones JP, Park JB, Park HJ, Lee HJ, Wong EK, Min BI, New findings of the correlation between acupoints and corresponding brain cortices using functional MRI. Proc. of the National Academy of Sciences of the United States of America, 1998,95(5):2670?2673.
    [31] Li G, Cheung RT, Ma QY, Yang ES. Visual cortical activations on fMRI upon stimulation of the vision-implicated acupoints. Neuroreport, 2003,14(3):669?673.
    [32] Yan B, Li K, Xu JY, Wang W, Li KC, Liu H, Shan BC, Tang XW, . Acupoint-Specific fMRI patterns in human brain. Neuroscience Letters, 2005,383(3):236?240.
    [33] Gareus IK, Lacour M, Schulte AC, Hennig J. Is there a BOLD response of the visual cortex on stimulation of the vision-related acupoint GB 37? Journal of Magnetic Resonance Imaging, 2002,15(3):227?232.
    [34] Parrish TB, Schaeffer A, Catanese M, Rogel MJ. Functional magnetic resonance imaging of real and sham acupuncture: Noninvasively measuring cortical activation from acupuncture. IEEE Engineering in Medicine and Biology Magazine, 2005,24(2): 35?40.
    [35] Hu KM, Wang CP, Xie HJ, Henning J. Observation on activating effectiveness of acupuncture at acupoints and non-acupoints on different brain regions. Zhongguo Zhen Jiu, 2006,26(3):205?207 (in Chinese with English abstract).
    [36] Li G, Liu HL, Cheung RTF, Hung YC, Wong KKK, Shen GGX, Ma QY, Yang ES. An fMRI study comparing brain activation between word generation and electrical stimulation of language-implicated acupoints. Human Brain Mapping, 2003,18(3):233?238.
    [37] Wu MT, Sheen JM, Chuang KH, Yang PC, Chin SL, Tsai CY, Chen CJ, Liao JR, Lai PH, Chu KA, Pan HB, Yang CF. Neuronal specificity of acupuncture response: A fMRI study with electroacupuncture. NeuroImage, 2002,16(4):1028?1037.
    [38] Dowman R, Darcey T, Barkan H, Thadani V, Reberts D. Human intracranially-recorded cortical responses evoked by painful electrical stimulation of the sural nerve. NeuroImage, 2007,34(2):743?763.
    [39] Zeng Y, Liang XC, Dai JP, Wang Y, Yang ZL, Li M, Huang GY, Shi J. Electroacupuncture modulates cortical activities evoked by noxious somatosensory stimulation in human. Brain Research, 2006,1097(1):90?100.
    [40] Li A, Zhang J, Xie Y. Human acupuncture points mapped in rats are associated with excitable muscle/skin-nerve complexes with enriched nerve endings. Brain Research, 2004,1012(1-2):154?159.
    [41] Sakai S, Hori E, Umeno K, Kitabayashi N, Ono T, Nishijo H. Specific acupuncture sensation correlates with EEGs and autonomic changes in human subjects. Autonomic Neuroscience, 2007,133(2):158?169.
    [42] Law PP, Cheing GL. Optimal stimulation frequency of transcutaneous electrical nerve stimulation on people with knee osteoarthritis. Journal of rehabilitation medicine, 2004,36(5):220?225.
    [43] Kleinhenz J, Streitberger K, Windeler J, Güβbacher A, Mavridis G, Martin E. Randomized clinical trial comparing the effects of acupuncture and a newly designed placebo needle in rotator cuff tendonitis. Pain, 1999,83(2):235?241.
    [44] Calandre EP, Hidalgo J, Garcia-Leiva JM, Rico-Villademoros F. Trigger point evaluation in migraine patients: An indication of peripheral sensitization linked to migraine predisposition? European Journal of Neurology, 2006,13(3):244?249.
    [45] Lao L, Bergman S, Langenberg P, Wong R, Berman B. Effecacy of Chinese acupuncture on postoperative oral surgery pain. Oral Surgery, Oral Medicine, Oral Pathology, 1994,79(4):423?428.
    [46] Hsieh JC, Tu CH, Chen FP, Chen MC, Yeh TC, Cheng HC, Wu YT, Liu RS, Ho LT. Activation of the hypothalamus characterizes the acupuncture stimulation at the analgesic point in human: A positron emission tomography study. Neuroscience Letters, 2001, 307(2):105?108.
    [47] Yoo SS, Teh EK, Blinder RA, Jolesz FA. Modulation of cerebellar activities by acupuncture stimulation: Evidence from fMRI study. NeuroImage, 2004,22(2):932?940.
    [48] Napadow V, Makris N, Liu J, Kettner NW, Kwong KK, Hui KS. Effects of electroacupuncture versus manual acupuncture on the human brain as measured by fMRI. Human Brain Mapping, 2005,24(3):193?205.
    [49] Pariente J, White P, Frackowiak RS, Lewith G. Expectancy and belief modulate the neuronal substrates of pain treated by acupuncture. NeuroImage, 2005,25(4):1161?1167.
    [50] Zald DH. The human amygdala and the emotional evaluation of sensory stimuli. Brain Research Reviews, 2003,41(1):88?123.
    [51] Biella G, Sotgiu ML, Pellegata G, Paulesu E, Castiglioni I, Fazio F. Acupuncture produces central activations in pain regions. NeuroImage, 2001,14(1):60?66.
    [52] Casey KL. Forebrain mechanisms of nociception and pain: Analysis through imaging. Proc. of the National Academy of Sciences of the United States of America, 1999,96(14): 7668?7674.
    [53] Pomeranz B. Acupuncture analgesia: Basic research. In: Stux G, Hammerschlag R, eds. Clinical Acupuncture: Scientific Basis. Berlin: Springer-Verlag, 2001. 1?28.
    [54] McMahon S, Koltzenburg M. Wall and Melzack’s Textbook of Pain. 5th ed., Churchill Livingstone, 2005.
    [55] Zhang WT, Jin Z, Cui GH, Zhang KL, Zhang L, Zeng YW, Luo F, Chen CAN, Han JS. Relations between brain network activation and analgesic effect induced by low vs. high frequency electrical acupoint stimulation in different subjects: A functional magnetic resonance imaging study. Brain Research, 2003, 982(2):168?178.
    [56] Napadow V, Webb JM, Pearson N, Hammerschlag R. Neurobiological correlates of acupuncture. The Journal of Alternative and Complement Medicine, 2006,12(9):931?935.
    [57] Price DD, Rafii A, Watkins LR, Buckingham B. A psychophysical analysis of acupuncture analgesia. Pain, 1984,19(1):27?42.
    [58] Melzack R, Wall PD. Pain mechanisms: A new theory. Science, 1965,150(699):971?979.
    [59] Tran TD, Hoshiyama M, Inui K, Kakigi R. Electrical-Induced pain diminishes somatosensory evoked magnetic cortical fields. Clinical Neurophysiology, 2003,114:1704?1714.
    [60] Czura CJ, Tracey KJ. Autonomic neural regulation of immunity. Journal Internal Medicine, 2005,257(2):156?166.
    [61] Nishijo K, Mori H, Yosikawa K, Yazawa K. Decreased heart rate by acupuncture stimulation in humans via facilitation of cardiac vagal activity and suppression of cardiac sympathetic nerve. Neuroscience Letters, 1997,227(3):165?168.
    [62] Knardahl S, Elam M, Olausson B, Wallin BG. Sympathetic nerve activity after acupuncture in humans. Pain, 1998,75(1):19?25.
    [63] Tracey KJ. The inflammatory reflex. Nature, 2002,420(6917):853?859.
    [64] Napadow V, Dhond RP, Purdon P, Kettner N, Makris N, Kwong KK, Hui KKS. Correlating acupuncture fMRI in the human brainstem with heart rate variability. In: Proc. of the 2005 IEEE Engineering in Medicine and Biology the 27th Annual Conf. IEEE Service Center, 2005. 4496?4499. 附中文参考文献: [1] 林昭庚,鄢良.针灸医学史.北京:中国中医药出版社,1995.
    [2] 经络十讲编写组.经络十讲编写组.经络十讲.上海:上海人民出版社,1976.
    [3] 王启才,高俊雄.经络的研究及临床应用.北京:中国古籍出版社,1998.
    [4] 朱兵.针灸的科学基础.青岛:青岛出版社,1998.
    [35] 胡卡明,王承平,谢慧君,海宁.针刺穴位与非穴位激活不同脑区的效应观察.中国针灸,2006,26(3):205?207.
    相似文献
    引证文献
引用本文

张毅,刘鹏,田捷,秦伟,梁继民.针刺效应的神经影像学研究.软件学报,2009,20(5):1207-1215

复制
分享
文章指标
  • 点击次数:7543
  • 下载次数: 10743
  • HTML阅读次数: 0
  • 引用次数: 0
历史
  • 收稿日期:2008-07-27
  • 最后修改日期:2008-12-15
文章二维码
您是第位访问者
版权所有:中国科学院软件研究所 京ICP备05046678号-3
地址:北京市海淀区中关村南四街4号,邮政编码:100190
电话:010-62562563 传真:010-62562533 Email:jos@iscas.ac.cn
技术支持:北京勤云科技发展有限公司

京公网安备 11040202500063号