It is an important and hard technique problem in the area of color printing to keep the accordance of color between the different devices. In this paper, from the view of machine learning, a new color space transformation method based on machine learning is presented. Using the basic ideas of science discovery, it successfully solves the automatic and general problem in the different color ink printers. The experimental results show that this approach is superior to the traditional methods. Currently, this technique has been applied to the new products in the color ink printer markets, under the cooperation with Canotec Corporation Incorporated in Japan.