In this paper, a new run-time pointer aliasing disambiguation method, called SHRTD (software/hardware run-time disambiguation), which combines hardware and software techniques is presented. During run time, the SHRTD method lets function units execute NOPs to implement the postponement of the incorrect memory load operation and its successive operations. To guarantee the consistency of the execution sequence of all postponed operations, the order of function units which executes NOPs and the number of NOPs must be determined during compiler time. The SHRTD can be used for irreversible code, and it has very limited compensation code space and no serious rerollability problem. The SHRTD method solves pointer aliasing problem efficiently and makes it possible to obtain potential instruction-level parallel speedup.