In rich-resource scenarios, using similarity translation as the target prototype sequence can improve the performance of neural machine translation. However, in low-resource scenarios, due to the lack of parallel corpus resources, the prototype sequence cannot be matched, or the sequence quality is poor. To address this problem, this study proposes a low-resource neural machine translation approach with multi-strategy prototype generation, and the approach includes two phases. (1) Keyword matching and distributed representation matching are combined to retrieve prototype sequences, and the pseudo prototype generation approach is leveraged to generate available prototype sequences during retrieval failures. (2) The conventional encoder-decoder framework is improved for the effective employment of prototype sequences. The encoder side utilizes additional encoders to receive prototype sequences. The decoder side, while employing a gating mechanism to control information flow, adopts improved loss functions to reduce the negative impact of low-quality prototype sequences on the model. The experimental results on multiple datasets show that the proposed method can effectively improve the translation performance compared with the baseline models.