Mouse based target selection will require much movement when locating target across long distance on large display. On the other hand, eye tracking technique can locate target more easily and quickly across long distance. Hence, eye tracking has a high potential for fast targets selection on large displays. However, eye tracking still faces the challenges, such as low accuracy, and high error rate of selection operation, especially for gaze-only interaction. This study proposed a multimodal interaction method that combined gaze with gestures. This method utilized gaze for rough selection first, and then utilized hand gesture to confirm accurate selection. Furthermore, in order to keep the selection accuracy when targets are small and crowded, authors used semi-fixed gaze cursor and secondary selection mechanism to optimize the selection process. Finally, the method conducted a user study in different levels of target sizes and distance among targets. The results show that the selection speed and accuracy rate of proposed method are higher than those of the method only using gaze with 16% and 82.6% respectively. In addition, for the selection of the hierarchical menu items, the selection speed and accuracy rate of proposed method are higher than the those of method only using gaze with 13.6% and 55.7% respectively. In addition, the overall performance of proposed method is similar to the mouse based selection method, and it also validates the effectiveness of the proposed method.